#Corresponding authors:
DafengLiu, Yanfeng Zhu,
No.377 Jingming Road, Jinjiang District, Chengdu City, Sichuan
ProvinceChengdu610066, China
No.783, Xindu Avenue, Xindu District, Chengdu City, Sichuan Province
Chengdu 610500, China
Phone: +8613094494836: +8613648098858
E-mail address: ldf312@126.com ; cmc_zhuyanfeng@163.com
1. Abstract
1.1. Background: COVID-19 patients with lower immunonutritional status have a lower prognosticnutritional index (PNI) and are more likely to have severe disease and a poorprognosis.
1.2. Objectives: This study aims to evaluate the relationship between PNI level and diseaseprogression and prognosis in COVID-19 patients.
1.3. Methods: This retrospective analysis examined the PNI level of 1228 patientsdiagnosed with COVID-19. Patients were categorized into four groups: PNI1 group (PNI<50.65), PNI2 group (PNI 50.65-53.75), PNI3 group (PNI 53.76-57.20), and PNI4 group (PNI>57.20), based on the quartile value of PNI at admission.Comparisons were made between the four groups regarding clinical and outcomedata, and assessments were conducted to determine the association between PNI and disease progression and prognosis in patients with COVID-19.
1.4. Results: As PNI levels decreased from the upper to thelower quartile group, HGB, ALB, TP, and TLC levels also decreased. Additionally, patient age increased, and there were longer coronavirus negativeconversion times and hospitalization durations. According to the multipleregression analysis, the severity of illness was associated with PNI levels, nutritional risk, and NRS2002 score upon admission. Furthermore, the Prognostic Nutritional Index (PNI), nutritional risk, and NRS2002 score during admission areall significant prognostic factors. The PNI demonstrates a high degree ofaccuracy in predicting severe illness and mortality among COVID-19 patients.
1.5. Conclusions: A low PNI is significantly correlated with disease progression anda poor prognosis in COVID-19 patients. Early intervention for malnutrition isnecessary to lower the incidence of critical illness in individuals with a PNIlower than 49.12. Patients with a PNI lower than 40.45 necessitate continuousnutritional support to decrease mortality and enhance the likelihood ofrecovery.
2. Keywords: 2019 coronavirus disease (COVID-19), dietary risk, prognostic nutritional index(PNI), disease progression, prognosisClinical Trial
Citation:
DafengLiu, Yanfeng Zhu. Low Prognostic Nutritional Index Is Closely Related To Disease Progression And Poor Prognosis In Patients With COVID-19 In Chengdu. Journal of Clinical Cases 2024.
