Journal of Clinical Cases

A Rare Case Of Thymus Lipofibroadenoma

AV Shilov, AM Avdalyan, AS Shargin, NV Boriskin, AV Levitsky and DN Protsenko

Department
Moscow State Budgetary Institution of Health Care “Moscow Multidisciplinary Clinical Center “Kommunarka” of the Department of Health of the City of Moscow”, 8/3, Sosensky Stan street, Kommunarka, 108814. Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, 20/1, Delegatskaya street, Moscow, 127473. The Russian National Research Medical University named after N.I. Pirogov, 1, Ostrovityanova street, Moscow, 117997. Peoples’ Friendship University of Russia, 6, Miklukho-Maklaya street, Moscow, 117198 UK

Corresponding Author: Avdalyan Ashot

ABSTRACT

1.1. Background: Infants often have gastroesophageal reflux disorder (GERD), and Cisapride is prescribed for treatment. This study aimed to assess the effectiveness of Cisapride in treating GERD in newborns while considering its adverse effects and its removal from the market.
1.2. Methods: A meta-analysis is performed on randomized clinical trial studies conducted on Cisapride over the period 1987 to 2000, using the fixed-effect and random-effect models. Twelve clinical trials, with 512 infants (284 Cisapride treated and 228 Control Group) were chosen.
1.3. Results: According to a clinical score with a -0.72 weighted mean difference (WMD), a 2.94 quantile difference, and a P-value of 0.78, there is no evidence that Cisapride reduces the risk of vomiting, arrhythmia, or esophagitis compared with alternative treatments. 24-hour esophageal pH measurements found that the mean reflux rate was somewhat lower in Cisapride-treated neonates. Two trials indicated that Cisapride therapy was ineffective, with a WMD value of 5.34 and a confidence interval (CI) ranging between -8.41 4.81. Six studies indicated the same efficacy of Cisapride and Control with WMD -0.42 and CI value of 0.47.
1.4. Conclusion: There was no significant variance in unfavorable conditions. Cisapride showed no clinically significant effects in infants with GERD.