Journal of Clinical Cases

Causal Association Between Adipokines And Lung Cancers: A Two-Sample Mendelian Randomization Study

Wenhua Hu,yanmingLin ,Guowei Wu,Shiliang Li,Zhibin Lin,Yuting Chen,Zhen Cheng,, Junxuan Zeng and Yongcun Wang

1. Pathological Diagnosis and Research Center, The Affiliated Hospital of Guangdong Medical University, Zhanjiang524023 China.
2. Department of Pulmonary Oncology, The Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China.

Corresponding Author: Yongcun Wang

ABSTRACT

Background:The involvement of certain adipokines link to carcinogenesis, development, and prognosis. However, the roles of adipokines in lung cancer and its histological subtypes remains indistinct. Therefore, the aims of this study are to explore the causal relationship between adipokines and lung cancers.

Methods:Summary-level data for exposures (six adipokines) and outcomes (lung cancer and its histological subtypes) were collected from the IEU OpenGWAS, International Lung Cancer Consortium(ILCCO) and lectures. Two-sample mendelian randomization (MR) was conducted to estimate the causality by employing single nucleotide polymorphisms (SNPs) as instrument variables (IVs).

Results:LEPR was associated with risk of lung squamous cell carcinoma (LUSC, OR: 1.05, 95% CI: 1.01-1.08; P < 0.0125), and no other adipokines associated with lung cancer and its histological subtypes (P > 0.05).

Conclusion:This results provide the specific adipokines may act a vital role in risk of LUSC.

Keywords:Adipokines, Lung caner, histological subtypes, Mendelian randomization, causal association