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Tio2 Nanoparticles To Improve The Hair Growth Effect Of Minoxidil
Bongrae Cho
Department of Applied Chemistry, Cheongju University, Cheongju 28503, South Korea
Corresponding Author: Bongrae Cho
Published Date: 26 Dec 2023; Received Date: 08 Dec 2023
ABSTRACT
Background: Minoxidil has some problems with low efficiency of transdermal delivery and side effects like red spots and itch. In this research, TiO2 nanoparticles were developed to increase the hair growth of minoxidil even with less amount and fewer number of application than the recommended. Hollow porous TiO2 nanoparticles were made and characterized with FESEM(field emission scanning electron microscope). They had porous nanosphere structures with diameter in the range of 25 nm to 55 nm. Minoxidil-loaded TiO2 nanoparticles showed 67.7% increase of hair growth which is approximately 5 times, compared to 13.68% of hair growth got with application of only minoxidil solution after 6 months. Our results showed that minoxidil-loaded TiO2 nanoparticles improve hair growth of minoxidil even with less amount and fewer number of application than the recommended and show no significant cytotoxicity.
Key Words: TiO2 nanoparticle, minoxidil, hair growth, hollow porous nanoparticle, minoxidil-loaded TiO2 nanoparticle.